Application of 78597-27-0, A common heterocyclic compound, 78597-27-0, name is 6-Iodo-1H-benzo[d]imidazole, molecular formula is C7H5IN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
b) 5-((Trimethylsilyl)ethynyl)- 1 H-benzo [djimidazoleA solution of of the compound of Intermediate Example 12(a) (0.7 g, 2.56 mmol) inDMF-Et3N (1:1; 10 ml) was degassed by N2 bubbling for 15 mm. Pd(dppf)Cl2 (0.11g,. 0.14. mmol, 0.05 eq), copper(]) iodide (0.054g, 0.25 mmol, 0.1 eq) and ethynyltrimethylsilane.(0.3 g, 3.15 mmol; 1.1 eq) were added sequentially and the mixture was stirred for 12 h at RT. The mixture was quenched and extracted as in Intermediate Example 1. The solvent was distilled off and the crude residue was recrystallized fromhexane to afford the title product in 57 % yield (0.35 g). LC-MS (ESI): Calculated mass:214.09;Observed mass: 215.5 jM+H] + (rt: 0.22 mm).
The synthetic route of 78597-27-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORION CORPORATION; RAJAGOPALAN, Srinivasan; APPUKUTTAN, Prasad; NARASINGAPURAM ARUMUGAM, Karthikeyan; UJJINAMATADA, Ravi Kotrabasaiah; GEORGE, Shyla; LINNANEN, Tero; WO2014/162039; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem