19485-38-2, name is 1-Methylimidazole-4,5-dicarboxylic Acid, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 19485-38-2
Example 238 HATU (83 mg, 0.22 mmol) was added to a mixutre of l-methyl-lH-imidazole-4,5- dicarboxylic acid (17.8 mg, 0.10 mmol) and an HCl salt of Intermediate 32 (80 mg, 0.21 mmol) in DMF (1 mL) and DIPEA (0.091 mL, 0.52 mmol) and the reaction mixture was stirred at rt for 16 h. The reaction was filtered and purified by preparative HPLC to afford the title compound (10.5 mg). LC-MS retention time = 2.85 min; m/z = 827.2 [M+H]+. (Column: Waters Acquity UPLC BEH C18, 2.1 x 50 mm, 1.7-muiotaeta particles; Mobile Phase A: 5:95 acetonitrile:water with 10 mM ammonium acetate; Mobile Phase B: 95:5 acetonitrile: water with 10 mM ammonium acetate; Temperature: 50 C; Gradient: 0- 100% B over 3 minutes, then a 0.75-minute hold at 100% B; Flow: 1.0 mL/min;
The synthetic route of 19485-38-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIIV HEALTHCARE (No.5) LIMITED; BENDER, John A.; LOPEZ, Omar D.; NGUYEN, Van N.; YANG, Zhong; WANG, Alan Xiangdong; WANG, Gan; MEANWELL, Nicholas A.; BENO, Brett R.; FRIDELL, Robert A.; BELEMA, Makonen; THANGATHIRUPATHY, Srinivasan; (350 pag.)WO2016/172425; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem