Adding a certain compound to certain chemical reactions, such as: 6953-65-7, name is (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6953-65-7, Application In Synthesis of (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol
A mixture of (5 -chloro- 1 H-benzo [d]imidazol-2-yl)methanol (7a) (500 mg, 2.738mmoles, 1 eq.), 4-bromobutyronitrile (466 mg, 1.15 eq.), cesium carbonate (1.338 g,1.5 eq.) and potassium iodide (45 mg, 0.1 eq.) in acetonitrile (5 mL) was refluxedovernight. The mixture was then cooled and filtered. The filtrate was evaporated under vacuum and the residue was treated with ethyl acetate (30 ml) and brine (20 ml). The separated organic layer was dried (Na2SO4), filtered and the solvent was evaporated under vacuum. The residue was purified by column chromatography (eluent: CH2C12:methanol from 1:0 to 15:1) to yield 732mg (54%) of a mixture containing two regioisomers (5- and 6-chloro derivatives) in a 1/1 ratio. This mixture was further separated by SFC to provide the pure regio-isomer (7b).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN SCIENCES IRELAND UC; HU, Lili; DEMIN, Samuel, Dominique; VENDEVILLE, Sandrine, Marie, Helene; TAHRI, Abdellah; RABOISSON, Pierre, Jean-Marie, Bernard; WO2015/158653; (2015); A1;,
Imidazole – Wikipedia,
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