Electric Literature of 29518-68-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
(a) 1 -[2-(I H-B enzimidazol-2-y) ethyl] thiourea; {2-(lH-Benzimidazol-2-yl)ethylamine was made as the dihydrochloride salt according to a procedure described by Nicolaou etaJ. Bioorg. Med. Chem., 1998, 6, 1185-1208 and pretreated with DIPEA (2.07 mL, 11.86 mmol) for 5 minutes.} To a suspension of 2-(1H- benzimidazol-2-yl)ethylarnine (1.39 g, 5.93 mmol) in dichloromethane (20 mL) was added benzoyl isothiocyanate (0.88 mL, 6.52 mmol). After 1 h, the reaction mixture was concentrated in vacuo. Ammonia in methanol (7N, 30 mL) was then added and the reaction stirred another 4 h. The excess ammonia and methanol were removed in vacuo and dichloromethane (15 mL) was added. The solid was removed by filtration and the filtrate concentrated in vacuo and purified by flash chromatography (methanol/dichloromethane, 5% thenltheta%) to give the title compound as a solid (1.12 g, 86% yield). 1H NMR (DMSO-de) delta ppm 12.28 (IH), 7.85-7.62 (2H), 7.49 (2H), 7.15-7.10 (2H), 7.05 (IH), 3.86 (2H), 3.04 (2H); MS (ESI) m/z 221 (M+l).
The synthetic route of 2-(1H-Benzo[d]imidazol-2-yl)ethanamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2007/120098; (2007); A1;,
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