Adding a certain compound to certain chemical reactions, such as: 14003-66-8, name is 4-Methyl-5-nitro-1H-imidazole, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14003-66-8, Computed Properties of C4H5N3O2
To a stirred suspension of 4(5)-methyl-5(4)-nitroimidazole (5 g, 0.04 mol) in benzaldehyde was added piperidine (3.95 g, 0.04 mol). The mixture was heated to 110 C for 2.5 h. When the reaction was complete and solid started separating, 100 mL ethanol was added to the reaction mixture. The mixture was allowed to cool to room temperature and filtered to obtain a yellow solid which was washed with ethanol and dried to get a pure compound. Yield 6.5 g, 77%; mp: 258-260 C; 1H NMR (DMSO-d6) delta 7.90 (s, 1H, Imid-H), 7.68-7.36 (m, 7H, CH=CH, Ar-H); 13C NMR (DMSO-d6) delta 143.73, 136.33, 136.10, 135.30, 130.93, 129.76, 129.65, 127.54, 114.64; HRMS (FAB), Calcd for C11H9N3O2: 216.0767 (MH+); obsd m/z 216.0769.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.
Reference:
Article; Tantravedi, Saritha; Chakraborty, Saibal; Shah, Niti H.; Fishbein, James C.; Hosmane, Ramachandra S.; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 4893 – 4903;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem