Synthetic Route of 10394-40-8,Some common heterocyclic compound, 10394-40-8, name is 1,6-Dimethyl-1H-benzo[d]imidazole, molecular formula is C9H10N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
STR44 An aqueous solution (100 ml) of 3.95 g of 1,6-dimethylbenzimidazole and 10 g of potassium permanganate was stirred at 50 C. for 2 hours and 2 g of potassium permanganate was further added to the mixture. The mixture was stirred at 80 C. for further 2 hours. After insoluble matters were filtered off, the filtrate was rendered pH 4 with 1 N hydrochloric acid and concentrated under reduced pressure to give 7.33 g of 1-methylbenzimidazole-6-carboxylic acid as the mixture with potassium chloride. The above compound was heated to reflux in 150 ml of methanol overnight in the presence of 3 ml of conc. sulfuric acid. The reaction solution was concentrated under reduced pressure and water was added to the concentrate.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,6-Dimethyl-1H-benzo[d]imidazole, its application will become more common.
Reference:
Patent; Yamanouchi Pharmaceutical Co., Ltd.; US4977175; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem