In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89088-69-7 as follows. Quality Control of 1-Methyl-1H-imidazol-4-amine hydrochloride
Intermediate 432-Chloro-7-(2-fluoroethyl)-Lambda/-(l -methyl- lH-imidazol-4-yl)-7H-pyrrolo[2,3-dlpyrimidin-4-amineThe solution of 2,4-dichloro-7-(2-fluoroethyl)-7H-pyrrolo[2,3-d]pyrimidine (Intermediate 44, 600 mg, 2.56 mmol) and 1 -methyl- lH-imidazol-4-amine hydrochloride (Intermediate 36, 523 mg, 3.08 mmol) was added to DIPEA (2686 mul, 15.38 mmol) in ethanol (5859 mul) and the reaction mixture was heated at 90 0C for 24 hours. Additional 1 -methyl- lH-imidazol-4-amine hydrochloride (Intermediate 36, 523 mg, 3.08 mmol) and DIPEA (2686 mul, 15.38 mmol) added to the reaction mixture and the mixture was heated at 90 0C for another 24 hours. The volatiles were removed under reduced pressure to afford a residue, which was dissolved in DCM/MeOH (10%) and washed with water. The organic layer was concentrated in vacuum, followed by purification by reversed phase HPLC (Gilson chromatography, 0%->50% MeCN/0.1% TFA H2O) to yield the title product (454 mg). LCMS: 297 [M+H]+.
According to the analysis of related databases, 89088-69-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin; WO2010/38060; (2010); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem