Synthetic Route of 857070-66-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 857070-66-7 name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of x-4 (0.0173 mol) and x-3 (0.026 mol) was stirred at 125C for 4 hours, and then taken up in CH2CI2/CH30H. The organic layer was washed with saturated K2C03 solution, dried (over MgSO4), filtered and the solvent was evaporated until dryness. The residue (9 g) was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH/NH4OH 90/10/0. 5; 20-45mum). Two fractions were collected and the solvent was evaporated. Yield: 0.7 g of intermediate x-5 (10%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem