Adding a certain compound to certain chemical reactions, such as: 53525-60-3, name is Ethyl 1-trityl-1H-imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53525-60-3, name: Ethyl 1-trityl-1H-imidazole-4-carboxylate
To a stirred solution of acetonitrile (0.32 g; 7.80 mmol) in tetrahydrofuran (20 ml) was addedsodium bis(trimethylsilyl)amide (15.7m1, 1.OM in THF, 15.69 mmol at 0C. The stirring wascontinued for 30 minutes and then a solution of ethyl 1 -trityl- 1 H-imidazole-4-carboxylate (XLV; 2 g; 5.23 mmol) in THF (20 ml) was added. The reaction mixture was stirred at 80C for 12 h. The reaction mixture was cooled, concentrated at reduced pressure and diluted with ice cold water. The aqueous layer was extracted with ethyl acetate, and the resulting organiclayer washed with brine, dried over Na2504, filtered and concentrated under vacuum to afford3-oxo-3-(1-trityl-1H-imidazol-4-yl)propanenitrile as a brown solid (XLVI; 1 g, 50% yield). MS (M+1) 378.34.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-trityl-1H-imidazole-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; NORGINE B.V.; BAKTHAVATCHALAM, Rajagopal; BASU, Manas Kumar; BEHERA, Ajit Kumar; VENKATESHAPPA, Chandregowda; HEWSON, Christopher Alexander; KADNUR, Sanjay Venkatachalapathi; KALINDJIAN, Sarkis Barret; KULKARNI, Bheemashankar; SAXENA, Rohit; SURESH, Juluri; VISWANATHAN, Vellarkad; ZAINUDDIN, Mohd; DHARSHINIS, Akila Parvathy; KRISTAM, Rajenda; WO2015/97122; (2015); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem