Synthetic Route of 92807-02-8, The chemical industry reduces the impact on the environment during synthesis 92807-02-8, name is Methyl 2-mercapto-1H-benzo[d]imidazole-4-carboxylate, I believe this compound will play a more active role in future production and life.
Example 42: [2- (4-ACETYLAMINO-BENZVLSULFANYL)-1 H-BENZIMIDAZOLE-4-CARBOXYLIC ACID] amide (42) (a) [2- (4-ACETYLAMINO-BENZYLSULFANYL)-1 M-BENZIMIDAZOLE-4-CARBOXYLIC ACID METHYL] ester [0135] A solution containing 85 mg of [2-MERCAPTO-1 H-BENZIMIDAZOLE-4-CARBOXYLIC] acid methyl ester (0.40 [MMOL)] in 4 mL DMF was cooled to 0 [C.] To this was added 130 mg CsCO3 (0.40 [MMOL)] followed by 91 mg of [4-ACETAMIDOBENZYL] chloride (0.49 [MMOL).] The reaction was stirred overnight, allowing it to warm to 23 C, and then concentrated in vacuo. The resulting crude material was suspended in pH 7 buffer and extracted with EtOAc (x3). The combined organic layers were dried [(MGS04),] filtered and concentrated. Purification by flash silica gel chromatography using a gradient solvent system (80% EtOAc/Hex to 100% EtOAc) gave 112 mg of product (0.31 mmol, 77%) as a colorless oil that crystallized upon standing. [0136] IR (KBr) 3283,3196, 1732,1709, 1666,1602, 1547,1514, 1448,1431, 1412, 1350,1302, 1297,1203, 1145,1124, [754 CM-1. 1H NMR (CDCL3) No. 2. ] 16 (s, 3H), 3.97 (s, [3H),] 4.56 (s, 2H), 7.23-7. 29 (m, 1 H), 7.36-7. 47 (m, 4H), 7.82 (d, [1 H, J = 7.] 7 Hz), 7.87 (d, 1 H, J = 7.7 Hz), 10.16 (br s, 1 H), not seen 1 H (NH). HPLC Rt = 5.643 min. [ANAL. (C18HL 7N303S)] C, H, N, S.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-mercapto-1H-benzo[d]imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER INC.; WO2003/106430; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem