37619-25-3, name is Methyl 1H-benzo[d]imidazole-4-carboxylate, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H8N2O2
Ste AG2: (1 H-Benzoimidazol-4-yl)-methanolTo a solution of 1 H-Benzoimidazole-4-carboxylic acid methyl ester (Step AG3, 1.0 g, 5.68 mmol) in THF (56.8 mL) under argon was added LiAIH4 (1 M in THF) (6.24 mL, 6.24 mmol), dropwise, causing a yellow coloration and a slight gas evolution. The reaction mixture was stirred at rt for 75 min. The medium was carefully quenched by addition of saturated aqueous NH4CI solution (50 mL). The slurry of aluminium salts was stirred for an hour at rt. The organic supernatant was decanted and the insoluble aluminium salts suspension was extracted with AcOEt (3 x 100 mL). The combined organic layers were dried over Na2S04, filtered and concentrated under reduced pressure to give a colorless oil (600 mg, 71 %). HPLC/MS (Method A) tR0.64 minute, M+H 149.0 . 1 H NMR (DMSO- cfe) Ppm 4.85 (br. s., 2 H) 5.19 (br. s., 1 H) 7.07 – 7.26 (m, 2 H) 7.48 (d, J=7.34 Hz, 1 H) 8.19 (s, 1 H) 12.35 – 12.64 (m, 1 H).
The synthetic route of 37619-25-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BERST, Frederic; FURET, Pascal; MARZINZIK, Andreas; WO2011/157787; (2011); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem