Application of 177760-04-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 177760-04-2, name is Ethyl 2-amino-1-methyl-1H-imidazole-5-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Aminoimidazole (0.700 g, 4.14 mmol) in acetic acid (7.3 mL) was added dropwise to an aqueous solution of sodium nitrite (3.6 mL, 11 M). The solution was stirred at room temperature for 4 h until no more N2 was formed. The reaction mixture was extracted with CH2Cl2 (1 x 20 mL), washed with brine (1 x 20 mL) and a saturated aqueous solution of Na2SO3 (1 x 20 mL). The organic layer was then dried over Na2SO4, filtered and concentrated to afford a crude yellow solid. Purification by flash chromatography using a prepacked 25 g silica column [solvent A: EtOAc; solvent B: hexanes; gradient: 7%A / 93%B (4 CV), 7%A / 93%B ? 60%A / 40%B (10 CV), 60%A / 40%B (2 CV); flow rate: 70 mL/min; monitored at 254 and 280 nm] afforded the nitroimidazole analogue 27 (0.510 g, 2.60 mmol, 63%) as a yellow solid.1H NMR (600 MHz, CDCl3) delta 7.74 (1H, s), 4.40 (2H, q, J = 7.1 Hz), 4.35 (3H, s), 1.41 (3H, t, J = 7.1 Hz).13C NMR (151 MHz, CDCl3) delta 159.08, 147.46, 134.67, 126.29, 61.84, 35.39, 14.18.
The synthetic route of Ethyl 2-amino-1-methyl-1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Winn, Blake A.; Shi, Zhe; Carlson, Graham J.; Wang, Yifan; Nguyen, Benson L.; Kelly, Evan M.; Ross, R. David; Hamel, Ernest; Chaplin, David J.; Trawick, Mary L.; Pinney, Kevin G.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 3; (2017); p. 636 – 641;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem