Adding a certain compound to certain chemical reactions, such as: 17450-34-9, name is Ethyl 2-(1-Imidazolyl)acetate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17450-34-9, Formula: C7H10N2O2
Under a dry argon atmosphere, a solution of 2 (6.05g, 39.2mmol) in dry THF (20mL) was added dropwise to the mixture of lithium aluminum hydride (3.00g, 79.1mmol) and dry THF (60mL) at 0C. The reaction mixture was stirred for 5min at 0C and for 4h at room temperature. Then, water (3mL), 15% sodium hydroxide aqueous solution (3mL), and water (9mL) were separately added dropwise to the reaction mixture at 0C. The resulting reaction mixture was stirred at room temperature for 12h and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluted with a mixed solvent of chloroform/methanol (10/1v/v). The fraction with an Rf value of 0.22 was collected and purified by distillation under reduced pressure twice to afford 1-(2-hydroxyethyl)imidazole (Im2OH) as colorless oil (2.386g, 54%)
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Reference:
Article; Ichikawa, Tsukasa; Wako, Tsuyoshi; Nemoto, Nobukatsu; Reactive and functional polymers; vol. 99; (2016); p. 1 – 8;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem