In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 70631-93-5 as follows. Product Details of 70631-93-5
To a stirred solution of 4-methyMH-imidazole-2-carboxylic acid (0.50 g) in DMF (20 mL) were added N,Odimethyl hydroxylamine hydrochloride (0.43 g), TEA (1.7 mL) and HATU (1.8 g). The mixture was stirred for 4 hours at 80C and stirred at room temperature for 2 days. The reaction mixture was concentrated in vacuo and the precipitates were filtered out. The filtrate was concentrated in vacuo and the residue was purified with amino-type silica gel chromatography (0″5 % MeOH in CHCI3) to give the title compound (0.41 g, 61 % yield) as pale yellow oil. MS (ESI) m/z : 170 [M+l]. RT = 0.206 min. LCMS condition : A.
According to the analysis of related databases, 70631-93-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; TAKASHIMA, Hajime; SASAKI, Toru; TANAKA, Nozomi; OTAKE, Norikazu; TSURUTA, Risa; YAMADA, Yousuke; MATSUDA, Yohei; OGATA, Yuya; (346 pag.)WO2018/216822; (2018); A1;,
Imidazole – Wikipedia,
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