Application of 50591-22-5, These common heterocyclic compound, 50591-22-5, name is 1-Methyl-1H-benzo[d]imidazol-5-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 98 NaH (204 mg, 8.49 mmol) in 47 DMF (5 mL) was added 203 1-methyl-1H-benzo[d]imidazol-5-ol (420 mg, 2.83 mmol) at 28 C. After being stirred for 5 minutes, 41 ethyl 2-bromoacetate (568 mg, 3.4 mmol) was added and the resulting mixture stirred for a further 16 h under the reaction was complete by TLC. The mixture was treated with 43 water (50 mL) and extracted with ethyl acetate (2¡Á20 mL). The water layer was treated with 2N 44 HCl until pH 3 and extracted with ethyl acetate (2¡Á20 mL). The combined organic layers were washed with brine (30 mL), dried over Na2SO4 and concentrated to give the 205 product (160 mg, 24.1%) as white solid which was used in next step without further purification. LCMS (m/z): 207.1 (M+1).
The synthetic route of 50591-22-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Epizyme, Inc.; Duncan, Kenneth W.; Chesworth, Richard; Boriack-Sjodin, Paula Ann; Munchhof, Michael John; Jin, Lei; (118 pag.)US2019/83482; (2019); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem