Synthetic Route of 2080-75-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2080-75-3, name is 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
5.2 5-Methoxy-6-nitro-1H-benzo[d]imidazol-2(3H)-one (9) A solution of 17.5% fuming nitric acid (12.5 mL, 48.9 mmol) was slowly added to 5-methoxy-1H-benzo[d]imidazol-2(3H)-one (0.25 g, 1.5 mmol) at 0 C, and the reaction was stirred for 1 h at 0 C, and at 20 C for 3 h. The reaction mixture was cooled to 0 C and neutralised with saturated aqueous NaHCO3 solution. The product was extracted with EtOAc (2 * 50 mL), washed with water, dried, and concentrated to give 9 (113 mg, 36%) as a yellow solid: 1H NMR (400 MHz, DMSO-d6) delta = 11.21 (br s, 1H), 10.81 (br s, 1H), 7.47 (s, 1H), 6.80 (s, 1H), 3.89 (s, 3H); MS ES+ve m/z 210 (M+H)+, 251 (M+H+MeCN)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methoxy-1H-benzo[d]imidazol-2(3H)-one, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Miah, Afjal H.; Abas, Hossay; Begg, Malcolm; Marsh, Benjamin J.; O’Flynn, Daniel E.; Ford, Alison J.; Percy, Jonathan M.; Procopiou, Panayiotis A.; Richards, Steve A.; Rumley, Sally-Anne; Bioorganic and Medicinal Chemistry; vol. 22; 15; (2014); p. 4298 – 4311;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem