Electric Literature of 154094-97-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 154094-97-0 name is 2-(1H-Imidazol-1-yl)ethanamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: At room temperature, to a red solution of compound 2 (150 mg,0.5 mmol) and triethylamine (0.14 mL, 1.0 mmol) in chloroform(40 mL), thionyl chloride (2.5 mL) was added dropwise. Themixture was stirred and heated under reflux for 5 h. The mixturegradually became a red solution. The reaction solution was then cooled to room temperature. The solvent was evaporated underreduced pressure. The residue was obtained under reduced pressurefor a period to get rid of most of the residual SOCl2 to give an orange solid residue. 4-(Dimethylamino)pyridine (70 mg,0.6 mmol) and different amine or alcohol derivative (1.80 mmol) inchloroform (30 mL) were added dropwise to the resultant residue.The reaction mixture instantaneously became a red solution. Thereaction mixture was heated under reflux for 5 h, and cooled toroom temperature. The solvent was evaporated under reducedpressure. The crude product was purified by silica gel columnchromatography to give the target compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Imidazol-1-yl)ethanamine hydrochloride, and friends who are interested can also refer to it.
Reference:
Article; Yu, Le-Mao; Zhang, Xiao-Ru; Li, Xiao-Bing; Yang, Yuan; Wei, Hong-Yu; He, Xi-Xin; Gu, Lian-Quan; Huang, Zhi-Shu; Pommier, Yves; An, Lin-Kun; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 525 – 533;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem