Synthetic Route of 83279-44-1, The chemical industry reduces the impact on the environment during synthesis 83279-44-1, name is 1H-Imidazol-1-amine hydrochloride, I believe this compound will play a more active role in future production and life.
EXAMPLE 8 1.20 g of 1-aminoimidazole hydrochloride are melted together with 2.70 g of 4-hydroxy-3,5-di-tert.-butylbenzoyl chloride on an oil-bath (about 200-210 bath temperture), whereby a vigorous gas evolution occurs. After 40 minutes, the solid residue is triturated with hot diisopropyl ether and filtered. The filter residue is taken up in water, treated with saturated sodium bicarbonate solution up to an alkaline reaction and extracted three times with methylene chloride. The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure on a rotary evaporator. The residue is taken up in ethyl acetate, heated and the 1-(4-hydroxy-3,5-di-tert.-butylbenzoylamino)imidazole is precipitated while hot with n-hexane. The precipitate is removed by filtration, washed once with n-hexane/ethyl acetate (2:1) and dried at 50 in a high vacuum; m.p. 245 (dec.).
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Reference:
Patent; Hoffmann-La Roche Inc.; US4908363; (1990); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem