Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 66247-84-5, name is (1H-Imidazol-4-yl)methanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: (1H-Imidazol-4-yl)methanamine hydrochloride
To the previous mixture containing intermediate a115 (0.44 g, 1.15 mmol, 73 wt percent) is added (1 /-/-imidazol-4-ylmethyl)amine dihydrochloride (0.59 g, 3.46 mmol, 3 eq) [from A. Turner et al., J. Am. Chem. Soc. (1949), 71 , 2801-2803.], and anhydrous cesium carbonate (1.88 g, 5.76 mmol, 5 eq) in dry DMF (15 ml_). The mixture is vigorously stirred at 60 0C for 3 h. The reaction mixture is cooled, concentrated under reduced pressure, diluted with water, and subjected to extraction with ethyl acetate (three times). The combined organic extracts are washed with brine, dried over anhydrous Na2SC>4, and evaporated. The residue (0.35 g) is purified by chromatography on silicagel (gradient CHCI3/MeOH from 20/1 to 10/1 v/v) to afford 5-chloro-2-(1 H-imidazol-4-ylmethyl)-1 ,4- dihydroisoquinolin-3(2H)-one 53 (0.15 g). Yield: 50 percent. LC-MS (MH+): 262/264.
According to the analysis of related databases, 66247-84-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; UCB PHARMA S.A.; WO2008/132139; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem