Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, A new synthetic method of this compound is introduced below., Safety of (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol
A mixture of m-1 (0.0273 mol) and m-2 (0.1095 mol) was stirred at 125C for 5 hours and then poured into a 10% solution OfK2CO3. The solution was saturated with K2CO3 (powder) and extracted with CH2CyCH3OH. The organic layer was separated, dried (over MgSO4), filtered and the solvent was evaporated. The residue (16 g) was purified by column chromatography over silica gel (eluent: CH2C12/CH3OH/NH4OH 88/12/0.5; 20-45 mum). The pure fractions were collected and the solvent was evaporated, yielding 5.4 g of intermediate m-3 (71%, melting point: 173C).
The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.