Electric Literature of 6232-92-4, A common heterocyclic compound, 6232-92-4, name is 6-Nitro-1H-benzo[d]imidazol-2-amine, molecular formula is C7H6N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Benzoyl chloride (0.51 mL, 4.4 mmol) was added to a solution of 2-amino-5-nitro-benzoimidazole (0.712 g, 4.00 mmol) in pyridine (15 mL) and the mixture was heated to 100°C for 0.5 h. Additional benzoyl chloride (0.19 mL, 1.6 mmol) was added and heating was continued for another 0.5 h. After removal of the solvent, the residue was treated with water (10 mL). The undissolved material was separated by filtration and washed with water (2 x 10 mL). After recrystallisation from pyridine (9 mL) / water (2 mL), N-(5-nitro-benzoimidazol-2-yl)benzamide (0.588 g, 2.08 mmol, 52 percent) was obtained. LC/ESI-MS: m/z = 283 [M+H]+; m/z = 281 [M-H]-; Rt =3.74 min.
The synthetic route of 6232-92-4 has been constantly updated, and we look forward to future research findings.