Application of 64038-64-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64038-64-8, name is Ethyl 2-mercapto-1H-imidazole-4-carboxylate belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2-thioxo-2,3-dihydro-1H-imidazole-4-carboxylic acid ethyl ester (5.81 mmol) and chloroacetone (6.97 mmol) in EtOH (8.0 mL) is heated at reflux for 120 min. The solvents are removed in vacuo and POCl3 (87.1 mmol) is added. The mixture is stirred at RT for 16 h and at reflux for 4 h, concentrated in vacuo and diluted with chloroform. Ice water is added and the mixture is neutralized by addition of Na2CO3. The layers are separated and the aq. layer is extracted with chloroform. The combined organic layers are dried over Na2SO4 and concentrated in vacuo to give a crude product which is purified by CC (heptane/EtOAc 9/1 to heptane/EtOAc 3/7). LC-MS: tR=0.73 min; [M+H]+=211.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 2-mercapto-1H-imidazole-4-carboxylate, other downstream synthetic routes, hurry up and to see.