Adding a certain compound to certain chemical reactions, such as: 5098-11-3, name is 5-Amino-1H-imidazole-4-carbonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5098-11-3, Application In Synthesis of 5-Amino-1H-imidazole-4-carbonitrile
Example 19: General procedure for the preparation of (thiophene-2- carbonyl)-imidazo[1 ,5-a]pyrimidines of general formula (I) following Scheme 1. N-[3-[8-(thiophene-2-carbonyl)-imidazo[1 ,5-a]pyrimidin-4-yl]-phenyl]-N- methyl-methanesulfonamidePart A A solution of thiophen-2-yl magnesium bromide was prepared from 1.0 g ( 42 mmol) of magnesium and 6.94 g (42 mmol) of 2-bromo-thiophene in 40 ml of dry tetrahydrofuran.To the solution of the Grignard reagent, cooled by an ice-salt bath, a mixture of 1 g (9.3 mmol)of 5-amino-1 H-imidazole-4-carbonitrile and 20 ml of dry tetrahydrofuran was slowly added with stirring. After standing at room temperature for 2 hours, the mixture was cooled and decomposed by adding, with stirring, 40 ml of 3M hydrochloric acid. When the decomposition was completed (1 hour at a temperature between 90-950C), the reaction mixture EPO
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