Adding a certain compound to certain chemical reactions, such as: 108035-45-6, name is 4-(1H-Imidazol-2-yl)benzoic acid, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108035-45-6, category: imidazoles-derivatives
A. (4-(lH-Imidazol-2-yl)phenyI)methanol.; 4-(lH-Imidazol-2-yl)benzoic acid (2.05 g, 10.9 mmol) was suspended in anhydrous tetrahydrofuran (60 mL) and cooled to -78 0C. A solution of lithium aluminum hydride (2.0M, 21.8 mL, 43.6 mmol) was added and the reaction was allowed to slowly warm to room temperature with stirring overnight. The reaction was quenched with methanol and the crude product adsorbed onto silica gel. Flash Chromatography (20% MeOH in EtOAc) afforded the title compound (1.6 g, 9.19 mmol, 84%) as a white solid. MS (ESI) m/z 175.1 [M+ 1]+.
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