50257-40-4, name is 1-((2,4,6-Triisopropylphenyl)sulfonyl)-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 50257-40-4
To a stirred suspension of NaH (60percent in oil dispersion) (2.9 g, 72 mmol) in dry THF (200 mL) at 0C was added in portions 16 (2.5 g, 15.8 mmol), followed by 2,4,6-triisopropyl-benzenesulfonylimidazole (13 g, 39.6 mmol), and the whole mixture was then stirred for 3 h. Cold H2O (80 mL) was added, and the resulting mixture was extracted with EtOAc (3 × 50 mL). The combined extracts were washed with brine (50 mL) and then dried (anhydrous Na2SO4). Evaporation of the solvent gave the crude product, which was purified by flash chromatography on silica gel (hexane/EtOAc, 50:1) to afford 17 (2.5 g, 42percent yield) as colorless oil. [alpha]D20 -2.0 (c = 1.00, CH2Cl2); 96percent ee; 1H NMR (300 MHz, CDCl3): delta 1.04 (t, J = 7.5 Hz, 3 H), 1.22-1.28 (m, 18 H), 2.02-2.07 (m, 2 H), 2.62-2.68 (m, 2 H), 2.81 (dd, J = 2.5, 4.8 Hz, 1 H), 2.90-2.93 (m, 2 H), 3.22-3.25 (m, 1 H), 4.12-4.16 (m, 2 H), 4.50-4.55 (m, 1 H), 7.18 (s, 2 H); 13C NMR (75 MHz, CDCl3): delta 12.4, 13.9, 22.9, 23.6, 24.7, 24.8, 29.8, 34.3, 45.5, 52.5, 72.9, 79.4, 85.2, 123.8, 130.7, 150.6, 153.7; HRMS (ESI): m/z [M+Na]+ calcd for C23H34O4SNa: 429.2070; found: 429.2073.
The synthetic route of 50257-40-4 has been constantly updated, and we look forward to future research findings.