In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23328-88-3 as follows. Computed Properties of C4H5BrN2
To a mixture of 5-(benzyloxy)-1,3-difluoro-2-nitrobenzene (2.65 g, 10 mmol) and potassium carbonate (2.76 g, 20 mmol) in 50 mL DMF was added 2-bromo-4-methylimidazole (1.46 g, 9.09 mmol) at RT. The resulting mixture was stirred at RT for 40 h. Majority of solvent was removed by rotavap. The residue was diluted with ethyl acetate and washed with water. Extraction with ethyl acetate, condensation on rotavap, followed by column chromatography using 20-40% ethyl acetate in hexane as eluent to provide 1.72 g (47% yield) product as a thick foam.
According to the analysis of related databases, 23328-88-3, the application of this compound in the production field has become more and more popular.