Related Products of 57667-50-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57667-50-2 name is 1-Propyl-1H-benzo[d]imidazol-2-amine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-Bromo-N-(1-propyl-1H-benzo[d]imidazol-2-yl)isophthalamide 13. A mixture of 5-bromoisophthalic acid (100 mg, 4.1 mumol), N-propylaminobenzamidazole (72 mg, 4.1 mumol), N-hydroxysuccinimide (56 mg, 4.9 mumol), DMAP (5 mg, 0.4 mumol) and EDC (234 mg, 1.2 mmol) were dissolved in methylene chloride (5 mL), treated with Hunig’s base (53 mg, 4.1 mumol) and stirred for 1 d to give 12. The reaction mixture was then treated with 9/1 MeOH/NH4OH (5 mL) and stirred for 2 h. The mixture was concentrated to a solid, dissolved in DMSO, added to a column and chromatographed (50 g isco C18, 0 to 100% MeOH with 0.2% formic acid) to give 13 (71 mg, 43%) as a white powder. LC/MS gave a single peak with m/z=401.1 [M+1]+ and 823.1 [2M+Na]+. 1H-NMR (dmso-d6) delta 12.77 (br s, 1H), 8.65 (br s, 1H), 8.45 (br s, 1H), 8.22 (br s, 1H), 8.17 (br s, 1H), 7.54-7.60 (m, 3H), 7.28 (t, J=8 Hz, 1H), 7.24 (t, J=8 Hz, 1H), 4.27 (t, J=7 Hz, 2H), 1.85 (h, J=7 Hz, 2H), 0.92 (t, J=7 Hz, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Propyl-1H-benzo[d]imidazol-2-amine, and friends who are interested can also refer to it.