Synthetic Route of 17289-26-8,Some common heterocyclic compound, 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The L-Proline or L-tert-Leucine-based amine was dissolved in DCM (2 M), followed by the additionof the imidazole based aldehyde (1-1.3 equiv.) and MgSO4H2O (1 g/5 mL solvent). The mixture wasstirred overnight at room temperature. Afterwards, solids were removed by filtration and the resultingsolution was concentrated in vacuo. The residue was dissolved in MeOH (2 M) and the solution wascooled to 0 C. NaBH4 (3 equiv.) and a catalytic amount of conc. HCl were added to this solution. Themixture was stirred for 30 min at 0 C, and 1 h at room temperature; after this period, an equal volumeof saturated NaHCO3 solution was added to quench the reaction. After washing with DCM and brine,the organic phase was separated, dried over anhydrous Na2SO4 and concentrated in vacuo to afford theraw product. Purification of the resulting raw material was carried out via column chromatography usingDCM and MeOH, eluted compound might be subsequently recrystallized from DCM and pentane.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-4-carbaldehyde, its application will become more common.