In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53484-15-4, name is 5-Bromo-1-methyl-1H-benzo[d]Imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H7BrN2
A microwave vial is charged with INTERMEDIATE J, 5-bromo-l-methyl- benzimidazole (12.1 mg, 0.0574 mmol), K3P04 (37.5 mg, 0.177 mmol), PdCl2(dppf)2 (3.6 mg, 0.0044 mmol), DMF (1 mL) and heated in the microwave for 15 minutes at 120C. The mixture is filtered on Millipore and concentrated to dryness. The residue is dissolved in MeOH (2 mL), treated with NaOMe (25% w/w, 10 0.044 mmol) and stirred overnight at room temperature. The mixture is then filter on SCX-2 SPE column, the column is wash with 2M NH3 in MeOH. The filtrate is concentrated to dryness and purified by reverse phase preparative HPLC to give the title compound (5.3 mg, 28%). XH NMR (400 MHz, Methanol-d4) delta 8.15 (s, 1H), 7.88 (m, 1H), 7.80 (m, 1H), 7.60 (m, 3H), 7.45 (m, 2H), 5.04 (d, J = 3.7 Hz, 1H), 4.50 (t, J = 3.5 Hz, 1H), 3.92 (s, 3H), 3.86 (m, 2H), 3.75 (t, J = 7.9 Hz, 1H), 3.65 (dd, J = 8.0, 3.1 Hz, 1H), 3.55 (m, 1H).
The synthetic route of 53484-15-4 has been constantly updated, and we look forward to future research findings.