Related Products of 22884-10-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22884-10-2, name is 2-(1H-Imidazol-1-yl)acetic acid belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
2.5 mL (0.029 mol) of phosphorus trichloride was added dropwise into the mixture of 1.6 g (0.013 mol) of 1H-imidazol-1-ylacetic acid (1), 2.2 g (0.027 mol) of phosphorous acid and 1.4 mL (0.008 mol) of [bmim][BF4] (A), or into the mixture of 5 mL of sulfolane and 1.4 mL (0.008 mol) of [bmim][BF4] (B) on stirring in ca. 30 min, and the contents of the flask were stirred at 75 C for 3 h. Further process including hydrolysis, pH adjustment, filtration and recrystallization was performed as described above to afford 2.9 g (75%, (A), Table 2, entry 3) and 3.6 g (93%, (B), Table 3, entry 1) of zoledronic acid dihydrate (2) in a purity of 99%. 31P NMR (D2O) delta: 17.6 and 17.3 respectively, delta[13]: 16.0.
The synthetic route of 2-(1H-Imidazol-1-yl)acetic acid has been constantly updated, and we look forward to future research findings.