Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23328-88-3, name is 2-Bromo-4-methyl-1H-imidazole, A new synthetic method of this compound is introduced below., Recommanded Product: 23328-88-3
To a stirred solution of 2-bromo-4-methyl-1H-imidazole (240 mg, 1.49 mmol) and cyclopropyl{4-[(2-{[6-(4,4, 5, 5-tetramethyl- 1, 3,2-dioxaborolan-2-yl )- 1 H-benzim idazol-2- yl]am ino}pyridin-4-yl)methyl]piperazin-1 -yl}methanone (150 mg, 299 iJmol) in dioxane (2.0 m L) and water (0.5 mL) was added sodium carbonate (130 mg, 1.22 mmol) and Pd(dppf)C12CHCl2 (48.8 mg, 59.7 pmol) and Tetrakis(triphenylphosphin)palladium (69.0 mg, 59.7 pmol). The mixture was heated to reflux for 24 h. Methanol was added, the mixture was filtered and the solvent was removed in vacuum. Silicagel chromatography gave 19.0 mg (13 % yield) of the title compound.LC-MS (Method 5): R1 = 2.31 mm; MS (ESIpos): m/z = 457 [M+H]1H-NMR (400 MHz, DMSO-d6) [ppm]: 0.691 (1.89), 0.711 (2.62), 0.718 (2.69), 0.731 (2.52),1.234 (0.47), 1.952 (0.59), 1.964 (0.84), 2.341 (6.66), 2.395 (0.88), 2.495 (10.55), 2.500(13.36), 2.504 (11.34), 3.169 (0.43), 3.309 (16.00), 3.565 (1.65), 3.718 (0.95), 6.986 (1.09),6.999 (1.14), 7.227 (1.50), 7.408 (1.77), 7.639 (1.33), 7.997 (2.12), 8.299 (1.25), 8.312 (1.25).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.