Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 23785-21-9, name is Ethyl 1H-imidazole-4-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 23785-21-9
Synthesis of Compound 8.1. Into a 100-mL 3-necked round-bottom flask, was placed ethyl lH-imidazole-5-carboxylate (1.4 g, 9.99 mmol, 1.00 equiv) and N,N- dimethylformamide (25 mL) was added. The reaction was cooled in an ice bath and then LiHMDS (IN in tetrahydrofuran) (11 mL, 1.10 equiv) was added. The reaction was stirred at R.T. Then amino diphenylphosphinate (2.8 g, 12.01 mmol, 1.20 equiv) was added at RT. The reaction was stirred for 2 h at 25 C. Then it was concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (100: 1). This provided 1.0 g (65%) of ethyl 1 -amino- lH-imidazole-5-carboxylate (8.1) as an off-white solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.