Electric Literature of 66121-69-5, These common heterocyclic compound, 66121-69-5, name is 1-Methyl-1H-imidazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4.1.3 Compounds with formula 3 according to Scheme 1a: Synthesis of 1-(1-Methyl-1H-imidazol-4-yl)-ethanone (3.3) for Example 2-16, 18, 19, 22, 26-28, 32-101, 103-175 43.4 ml 1.4M methylmagnesiumbromide in toluene were added dropwise to a mixture of 5.0 g 1-methyl-1H-imidazole-carbonitrile in 70 ml diethylether at 0 C. After 30 min, the mixture was warmed up to ambient temperature. After 1 h the reaction was quenched with 1M aqueous HCl solution and neutralised with saturated sodium bicarbonate solution. The reaction mixture was extracted with dichloromethane. The combined organic extracts were dried with magnesium sulfate and concentrated under reduced pressure. The crude material was purified by flash chromatography (dichloromethane/methanol=98/2) to give the intermediate 3.3. Yield: 4.8 g of 3.3 (75% content; 62% of theory); Analysis: [M+H]+=125
Statistics shows that 1-Methyl-1H-imidazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 66121-69-5.