Related Products of 87941-55-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87941-55-7, name is 4-Bromo-1-trityl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
A mixture of (3-(hydroxymethyl)phenyl)boronic acid (58.6 mg, 0.3 85 mmol),4-bromo-1-trityl-1H-immdazole (100 mg, 0.257 mmol), PdC12(dppf)-DCM adduct (10 mg,0.013 mmol) and potassium carbonate (178 mg, 1.28 mmol) in 1,4-dioxane (2 mL) and water (0.5 mL) was sparged 3 times with Ar. The reaction mixture then was heated at 150C in a microwave for 30 mm. The mixture was partitioned between DCM and water. The organic layer was washed with brine. The combined aqueous layers were extracted withDCM. The combined organics were dried with Na2SO4, filtered, and concentrated. The crude was purified by flash chromatography to give 278A (89 mg, 83%) as a white solid.MS(ESI) m/z 417.2 (M+H).
The synthetic route of 4-Bromo-1-trityl-1H-imidazole has been constantly updated, and we look forward to future research findings.