In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 95470-42-1 as follows. Quality Control of Ethyl 2-bromo-4-methyl-1H-imidazole-5-carboxylate
A solution of 2-bromo-4-methyl-lH-imidazole-5- carboxylic acid ethyl ester (1.0 g, 4.29 mmol) in dimethylformamide (DMF, 30 ml) was cooled to O0C, added with 60percent sodium hydride (NaH, 343 mg, 8.58 mmol) and stirred for 30 min. Iodomethane (0.8 ml, 12.87 mmol) was slowly added in droplets to the resulting solution which was then heated from 00C to room temperature with stirring for 4 hrs and added with water, followed by extraction with ethyl acetate. The extract was dried over MgSO4, filtered and concentrated in a vacuum. The purification of the concentrate thus obtain through silica gel column chromatography(hexane : ethyl acetate=5:l) afforded the object compound as a white solid (693 mg, 2.81 mmol, 65percent) . 1H-NMROOO MHz, CDCl3) sigma 1.38 (t, 3H, J = 7.1 Hz) ,2.46(s, 3H) , 3.88(s, 3H) , 4.33(q, 2H, J = 7.1 Hz);
According to the analysis of related databases, 95470-42-1, the application of this compound in the production field has become more and more popular.