Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 641571-11-1, name is 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 641571-11-1
A mixture of 46 (100 mg, 0.39 mmoi) and LiOH (28 mg, 1.17 mmoi) in THF/H20 (2/1 mL) was stirred at room temperature for 8 hours. TLC indicated the reaction was compiete. The reaction mixture was diiuted with water and acidified to pH 3 with aqueous HCi. The resuiting precipitate was fiitered washed with water and dried to give 47 (90 mg, 95%) as a white soiid. To a soiution of 47 (100 mg, 0.41 mmoi) in NMP (1 .5mL) was added SOCi2 (74 mg, 0.62 mmoi). The reaction was heated at 60 C for 1 hour before 3 (100 mg, 0.41 mmoi) and Et3N (166 mg, 1 .64 mmoi) were added. The resuiting mixture was stirred at 60 C for 3 hours. The reaction was directiy purified by reverse prep-H PLC and then siiica gei prep-TLC to give 3-(benzyioxy)-4-methyi-N-(3-(4-methyi- 1 H-imidazoi-1 -yi)-5-(trifiuoromethyi)phenyi)benzamide (25 mg, 13%) as a white soiid.
The synthetic route of 641571-11-1 has been constantly updated, and we look forward to future research findings.