These common heterocyclic compound, 120781-02-4, name is Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H7BrN2O2
1 g (4.565 mmol) of methyl 1-methyl-2-bromoimi- dazole-5-carboxylate (Vu-i) was dissolved in 10 ml of ethanol, 5.48 ml of iN NaOH (aq.) was added and the mixture was stirred at room temperature for 60 mm. After addition of 5.5 ml of iN HC1 (aq.) (adjusted to pH .-3), a white precipitate is formed. The mixture was concentrated to dryness and, in an ultrasonic bath, suspended in 6 ml of watet The white crystals were filtered oil and washed with 2 ml of water. The mother liquor was concentrated almost to dryness. The crystals were filtered off with suction and washed with a little watet The combined crystals were dried under oil pump vacuum. Yield: 890 mg (95% of theory).log P[a]: 0.31; ?H-NMR (d5-DMSO, 400 MHz); oe=3.82 (s, 3H),7.60 (s, 1H), 13.15 (s, 1H) ppm.
The synthetic route of Methyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate has been constantly updated, and we look forward to future research findings.