Adding a certain compound to certain chemical reactions, such as: 98873-55-3, name is 2-(1H-Imidazol-1-yl)acetonitrile, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 98873-55-3, Formula: C5H5N3
A 10 mL flask is charged with powdered KOH (159 mg, 2.43 mmol), DMSO (3 mL), purged with Argon and is cooled at 10CC with a water bath. A solution of 2-imidazol-1-ylacetonitrile (125 mg,1.17 mmol) and carbon disulfide (0.147 mL, 2.5 mmol) in DMSO (3 mL) is then added slowly to givean orange mixture. The cooling bath is removed and the reaction is stirred at room temperature for 30minutes. A solution of [2-bromo-1-(3-bromopyrazin-2-yl)ethyl] methanesulfonate (350 mg, 0.97 mmol)in DMSO (2 mL) is then added dropwise. After two hours, the reaction mixture is poured into H20 (15mL). The aqueous phase is extracted with dichloromethane, the combined organic phases are washedwith brine, dried with Na2504, filtered and evaporated to give a crude pale yellow residue. Purificationby chromatography on silica gel (heptanes I EtOAc, 5:1-*1:1-*1:3) afford (2E)-2-[4-(3-bromopyrazin-2-yl)-1 ,3-dithiolan-2-ylidene]-2-imidazol-1-yl-acetonitrile (Compound l.ao.25) as a yellow gum. 1HNMR(400 MHz, CDCI3): oe = 8.55 (d, J = 2.2 Hz, 1H), 8.41 (d, J = 2.2 Hz, 1H), 7.61 (s, 1H), 7.16 (s, 1H),7.03 (s, 1H), 5.67 (t, J= 5.5 Hz, 1H), 4.14 (dd, J= 5.5, 11.8 Hz, 1H), 3.91 (dd, J= 5.5, 11.8 Hz, 1H).MS (ESI): m/z= 366, 368 (M+1).
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