In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1008361-65-6, name is 5-Bromo-6-methoxy-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C8H7BrN2O
Step 3: To a stirred mixture of DMF (3 mL) and NaH (60% in mineral oil, 67 mg, 1.6 mmol) at 0 C under argonwas added 5-bromo-6-methoxy-1H-benzo[d]imidazole (346 mg, 1.5 mmol) from Step 2 of this Example in one portion.The mixture was stirred for 5 min at 0 C. A solution of 6-(chloromethyl)-2-(methylthio)benzo[d]thiazole (500 mg, 2.2mmol) from Step 4 of Example 36 in DMF (3 mL) was added dropwise. The mixture was stirred at 0 C for 1 h, thenallowed to warm slowly to rt and stirred for 6 h. The mixture was then partitioned between EtOAc (100 mL) and water(50 mL). The EtOAc layer was separated and washed with brine, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was purified by silica gel flash chromatography eluting with 100% EtOAc to afford thetwo regioisomers: Regioisomer 1; 6-((5-bromo-6-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole(127 mg, 20%). The structure was confirmed by comparison with NMR from the regiospecific synthesis of thesame compound described in Step 3 of Example 41. 1H NMR (300 MHz, CDCl3) delta 8.02 (s, 1H), 7.78 – 7.91 (m, 2H),7.47 (s, 1H), 7.25 (m, 1H), 6.70 (s, 1H), 5.43 (s, 2H), 3.82 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.Regioisomer 2; 6-((6-bromo-5-methoxy-1H-benzo[d]imidazol-1-yl)methyl)-2-(methylthio)benzo[d]thiazole (81 mg, 13%).1H NMR (300 MHz, CDCl3) delta 7.92 (s, 1H), 7.84 (d, J = 8.5 Hz, 1H), 7.48 (m, 2H), 7.34 (s, 1H), 7.25 (m, 1H), 5.40 (s,2H), 3.94 (s, 3H), 2.79 (s, 3H). LCMS (ESI) m/z 420 and 422 (M+H)+.
The synthetic route of 1008361-65-6 has been constantly updated, and we look forward to future research findings.