Synthetic Route of 41806-40-0, The chemical industry reduces the impact on the environment during synthesis 41806-40-0, name is 1-Methylimidazole-5-carboxylic Acid, I believe this compound will play a more active role in future production and life.
To a solution of 1-methyl-1 H-imidazole-5-carboxylic acid (45 mg, 0.36 MMOL) in DICHLOROMETHANE (3.6 mL) was added 6-CHLORO-2, 3,4, 9-tetrahydro-1H-carbazol-1- amine (95 mg, 0.43 MMOL), 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide (83 mg, 0.43 MMOL), and 1-hydroxybenzotriazole (54 mg, 0. 40 MMOL). After 5 minutes, triethylamine (100 muL, 0.72 MMOL) was added and the reaction was stirred at room temperature for 15 hours. The reaction mixture was diluted with dichloromethane, washed with water, 1 N hydrochloric acid, 1 N sodium hydroxide, brine, dried with magnesium sulfate, filtered, and concentrated. The residue was purified by PREPARATIVE chromatography (10-90% acetonitrile-water (0. 1% trifluoroacetic acid) ) and then diluted with ethyl acetate, washed with saturated aqueous sodium bicarbonate, and dried with magnesium sulfate to give 43 mg (36% yield) of a white SOLID. H-NMR (CDCI3) : 8 9.21 (s, 1H), 7. 43 (M, 1H), 7. 32 (s, 1H), 7. 30 (s, 1H), 7. 20 (d, 1H), 7.07 (dd, 1H), 6. 60 (d, 1H), 5.25 (m, 1H), 3. 81 (s, 3H), 2.67 (m, 2H), 2. 21 (m, 1H), 1.90 (m, 3H) ; MiS m/z 327 (M-1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylimidazole-5-carboxylic Acid, other downstream synthetic routes, hurry up and to see.