Related Products of 27231-33-0, A common heterocyclic compound, 27231-33-0, name is 4-Methyl-1H-benzo[d]imidazole-2(3H)-thione, molecular formula is C8H8N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 20 2,3-Dihydro-5-methyl-2-(2-pyridyl)thiazolo[3,2-a]benzimidazole 4-Methyl-2-mercaptobenzimidazole (13.32 g) was suspended in 2-methylpropan-2-ol (150 ml) and potassium tertbutoxide (9.04 g) added. The mixture was stirred for 2 hours and 2-(1,2-dibromoethyl)pyridine hydrobromide (27.68 g) added. The mixture was stirred at ambient temperature for 1 hour and then at reflux for 2 hours. The reaction mixture was filtered and the solid washed with ether. The filtrate was evaporated to dryness under reduced pressure and the residue combined with the first solid obtained. The combined material was dissolved in 2N HCl (100 ml). The aqueous solution was extracted with ethyl acetate, basified (Na2 CO3) and extracted with dichloromethane. The organic layer was dried (MgSO4) and the solvent removed under reduced pressure. The residue was purified on Florisil using chloroform as eluent and on silica using ethyl acetate as eluent to give the title compound (1.55 g) mp 128-130 C. Analysis: Found: C, 67.1; H, 5.0; N, 16.1. C15 H13 N3 S requires: C, 67.4; H, 4.9; N, 15.7%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.