Adding a certain compound to certain chemical reactions, such as: 17289-26-8, name is 1-Methyl-1H-imidazole-4-carbaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 17289-26-8, category: imidazoles-derivatives
To a solution of 15 (1.01 g, 9.18 mmol) in dry THF (10 mL) were added 5a (3.35 g. 10.1 mmol, 1.1 eq)and TMG (1.7 mL, 13.8 mmol, 1.5 eq) at 0 C, and the mixture was stirred for 24 h at rt. The reaction mixture was quenched with water and acidified with 1N aqueous HCl, and extracted with CH2Cl2. The aqueous layer was neutralized with sat. aqueous NaHCO3 and extracted with CH2Cl2. The combined organic extracts wered ried over anhydrous MgSO4, concentrated in vacuo to afford the crude product. The residue was purified by silica gel flash column chromatography (40:1 CHCl3 / MeOH). The obtained residue was washed with Et2O and the cake was dried in a house vacuum oven to afford 11a (1.90 g, 65%) as a white solid. IR (solid, cm-1) 1063, 1225, 1273, 1462, 1728, 2951, 32291H NMR (500 MHz, CDCl3) delta 3.68 (s, 3H), 3.79 (s, 3H), 5.18 (s, 2H), 6.56 (s, 1H), 6.95 (s, 1H), 7.31-7.43 (m,6H)13 C NMR (125 MHz, CDCl3) delta 33.5, 52.2, 67.1, 112.9, 121.4, 126.6, 128.0, 128.1, 128.4, 136.2, 137.7, 154.1,165.8FAB-MS : m/z 316 (M+H)+HRMS (ESI) Calculated for C16H18N3O4 316.1291 Found 316.1299
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-carbaldehyde, other downstream synthetic routes, hurry up and to see.