Related Products of 68282-53-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68282-53-1 name is 5-Methyl-1H-imidazole-4-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of Apim (2.81 g, 22.5 mmol) in dry methanol (17 mL) was added 4-methyl-5-imidazolecarboxaldehyde (2.17 g, 22.5 mmol). The resulting light-yellow suspension was heated to reflux for 3 h. The suspension was dissolved completely after 5 min. The solution was then stirred overnight at room temperature. After 0.5 h the solution turned orange in colour. The solvent was removed under reduced pressure to give an orange oil, which, on standing for 3 weeks, yielded the orange solid (5) (3.10 g, yield 76 %). M.p. 113-115C. C11H15N5 (217.27): Calc. C, 60.81; H, 6.96; N, 32.23. Found: C, 60.60; H, 6.72; N, 31.35%. 1H NMR (d6-DMSO): delta=8.23 (s, 1H), 7.64 (s, 1H), 7.61 (s, 1H), 7.18 (s, 1H), 6.91 (s, 1H), 4.04 (t, 2H, J=7.2Hz), 3.42 (t, 2H, J=6.6Hz), 2.32 (s, 3H), 2.03 (p, 2H, J=6.9, 6.6Hz) ppm. 13C NMR (d6-DMSO): delta=137.2, 128.3, 119.3, 57.3, 48.5, 43.9, 32.1ppm. IR (KBr): nu=3113, 1643, 1529, 1452, 1395, 1354, 1233, 1110, 1082, 826, 747cm-1. LC/TCOF-MS: Calc. for C10H14N5 [M+1]+ 218.3. Found 218.1%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Methyl-1H-imidazole-4-carbaldehyde, and friends who are interested can also refer to it.