Electric Literature of 1450-93-7, A common heterocyclic compound, 1450-93-7, name is 1H-imidazol-2-amine sulfate(2:1), molecular formula is C6H12N6O4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
C. A mixture of 2-((5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-2- oxopiperidin-3-yl)acetic acid (218 mg, 0.63 mmol), 2-aminoimidazole sulfate (83 mg, 0.63 mmol), BOP (278 mg, 0.63 mmol) and N,N-diisopropylethylamine (0.33 mL, 1.89 mmol) in dry DMF (5 mL) was stirred at 60 0C under argon for six hours. The mixture was diluted with water and the resulting solution was extracted with EtOAc (4x). The combined organic layer was washed with brine, dried over MgSO4, filtered and the filtrate was evaporated to dryness. The residue was purified by radial chromatography (0% to 5% methanol in CH2CI2) to give 2-[(5S)- 5-(3-cyclopentyloxy-4-methoxyphenyl)-2-oxo-3-piperidinyl]-N-(2-imid- azolyl)acetamide as a mixture of diastereomers (119 mg, 46%) as a white solid.
The synthetic route of 1450-93-7 has been constantly updated, and we look forward to future research findings.