Synthetic Route of 2963-77-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2963-77-1, name is 4-(1H-Benzo[d]imidazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows.
Example 42: Preparation of 4-(1H-Benzoimidazol-2-yl)-N-[4-(1H-benzoimidazol-2-yl)- PHENYLL-BENZAMIDE (Compound 115) Following Scheme 8, 4-(LH-BENZOIMIDAZOL-2-YL)-BENZOIC acid (60 mg, 0.25 mmol) and carbonyldiimidazole (45 mg, 0.3 mmol) were stirred in DMF (1.0 ml) at 80 C under Ar for 90 minutes. To this solution was added 4-(LH-BENZOIMIDAZOL-2-YL)- PHENYLAMINE (41 mg, 0.26 mmol), and the mixture was stirred at 55 C under Ar for overnight. Water (20 ml) was added after it was cooled to ambient temperature. The solid formed was collected by filtration and was washed with water (3 X 10 ml), and ethyl ether (4 X 10 ml). Recrystallization from acetone (30 ml) gave a white solid as a pure product (20 mg, 0.047 mmol, 23%). MS m/z = 429.98 (M+H) ; 1H NMR delta 13. 11 (s, 1 H), 12.84 (s, 1 H), 10.59 (s, 1 H), 8.35 (d, J=8.4 Hz, 2 H), 8. 17 (m, 4 H), 8.01 (d, J=8.4 Hz, 2 H), 7. 83-7. 51 (m, 4 H), 7.25 (m, 4 H).
The chemical industry reduces the impact on the environment during synthesis 4-(1H-Benzo[d]imidazol-2-yl)aniline. I believe this compound will play a more active role in future production and life.