Adding a certain compound to certain chemical reactions, such as: 75370-65-9, name is 4-Amino-1H-benzo[d]imidazol-2(3H)-one, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 75370-65-9, Safety of 4-Amino-1H-benzo[d]imidazol-2(3H)-one
Example 55: 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)acetamide (scheme 10) Preparation of 2-(4-(trifluoromethyl)phenyl)-N-(2,3-dihydro-2-oxo-1H-benzo[d]imidazol-4-yl)acetamide 4-trifluoromethylphenylacetic acid (300 mg, 1.47 mmol) was dissolved in 20 ml of THF and at 0C DEPC (0.28 ml, 1.3equiv) and amine 1a (260 mg, 1.2equiv.) were added to the solution. The mixture was warmed at 80C overnight, then evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column using AcOEt as eluant gave 150 mg of a white solid. Yield = 30% 1HNMR (DMSO, 400 MHz) delta 3.78 (2H, s), 6.75 (1H, d), 6.84 (1H, t), 7.05 (1H, d), 7.56 (2H, d, J = 8 Hz), 7.70 (2H, d, J = 8 Hz), 9.80 (1H, bs), 10.18 (1H, bs), 10.64 (1H, bs); [M+1] 336.1 (C16H12F3N3O2 requires 335.3).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Amino-1H-benzo[d]imidazol-2(3H)-one, and friends who are interested can also refer to it.