Simple exploration of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, A new synthetic method of this compound is introduced below., Safety of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde

To a solution of lactam 133b (110 mg, 0.497 mmol) in THF (2ml) at – 78 0C was added LDA (2M in THF/Heptane, 0.62 ml, 1.244 mmol). The reaction was stirred for 30 min. at – 780C, another 30 min. at -200C. Re-cooled to -780C. 3-methoxy-4- (4-methy.-1H-imidazol-1-yl)benzaldehyde was added as solid. The reaction mixture was stirred for 30 min. The reaction was quenched with sat. NaHCO3, extracted with EtOAc (2X), washed with brine (2X). Dried (MgSO4) and concentrated. The crude product was purified by flash chromatograph (7% MeOH/DCM) to afford compound 15d (110 mg, 50.6%).

The synthetic route of 870837-18-6 has been constantly updated, and we look forward to future research findings.