Some common heterocyclic compound, 13275-42-8, name is 2-(2-Bromophenyl)-1H-benzo[d]imidazole, molecular formula is C13H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 13275-42-8
General procedure: 2-(2-Bromophenyl)benzimidazole (2 mmol), guanidine hydrochloride (3 mmol), CuI (5 mol%) and potassium phosphate (6 mmol) were added to DMF in a 50 mL round bottom flask, and refluxed at 100 C for 16 h under nitrogen atmosphere. The reaction was detected by TLC. After the reaction was completed, cooled to room temperature. Then 50 mL of dichloromethane was added and washed by brine. The organic layer was concentrated with evaporator, and the residue was purified by column chromatography on silica gel to give the target compound (A-1 to A-3).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13275-42-8, its application will become more common.