Reference of 16681-59-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16681-59-7 name is 2-Bromo-1-methyl-1H-imidazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0461] 2-(2-chlorophenyl)-4-(piperazine-l-yl)quinazoline (91 mg, 0.281 mmol) was dissolved in NMP (3 mL) in a microwave reactor vial. Then 2-bromo-l- methylimidazole (0.05 mL, 0.561 mmol) was added and the mixture heated at 200 0C for 10 minutes in a microwave reactor. The mixture was poured into H2O, extracted with CH2Cl2, dried over Na2SO4, filtered, and concentrated in vacuo. The crude material was then purified by reverse phase HPLC (10% – 90% MeCNZH2O) to give the title compound. 1U NMR (400 MHz, CDCl3) delta 8.23 (m, IH), 8.13 (m, IH), 8.02 (m, IH), 7.92 (m, 2H), 7.67 (m, IH), 7.46 (m, 2H), 7.16 (d, IH), 6.83 (d, IH), 4.32 (m, 4H), 3.69 (m, 5H), 3.39 (m, 2H). MS (M/z, M+l), 405.5.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-methyl-1H-imidazole, and friends who are interested can also refer to it.