Reference of 492-98-8, A common heterocyclic compound, 492-98-8, name is 1H,1’H-2,2′-Biimidazole, molecular formula is C6H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Synthetic example 11 :1 ,r-bis(4-bromobenzyl)-1H,1 ‘H^’-biimidazole11To a mixture of 1H,1 W-2,2′-biimidazole (2.1 g, 15.7 mmol) in DMF at 0 “C was added NaH (1.32 g of a 60% dispersion in mineral oil, 32.8 mmol). The mixture was allowed to warm to room temperature and stirred for 30 min. 1-bromo-4- (bromomethyl)benzene (11.7 g, 46.8 mmol) was added and the mixture was heated to 80 “C and stirred (2h). The mixture was cooled to room temperature and saturated aqueous NH4CI (2 mL) was added and the mixture was concentrated. The mixture was diluted with CH2CI2 and Eta20 and the organic phase was separated. The aqueous phase was re-extracted (CH2CI2) and the combined organics were washed (saturated aqueous NaCI), dried (MgS04), filtered and concentrated to give a solid residue. The residue was purified by flash chromatography (EtOAc/CH2CI2 0:100 then 50:50 then 80:20) to give l .l’-bisi^bromobenzy -I ^^’-biimidazole (4.12 g, 56%) as a colourless solid. 1H NMR (CDCI3) 400 MHz) delta 5.66 (s, 4H), 6.86 -.6.91 (m, 4H), 6.93 (d( J 1.2 Hz, 2H), 7.11 (d, J 1.2 Hz, 2H), 7.33 – 7.39 (m, 4H); 13C NMR (CDCI3, 100 MHz) 5 50.2, 121.5, 121.7, 128.5, 129.1 , 131.8, 136.3, 138.0; HRMS (El) m/z 469.9741 C2oHi6 4Br2 [M]+” requires 671.2918.
The synthetic route of 492-98-8 has been constantly updated, and we look forward to future research findings.